This micrograph reveals some of the histopathologic changes found in an intestinal tissue specimen indicative of second-stage shigellosis. At this point in the pathogenesis, the Shigella sp. bacteria had penetrated the intestinal mucosal lining. See PHIL 6658, for a micrograph revealing cytoarchitectural changes seen in first stage shigellosis, and PHIL 15088, where you'll note the frank loss of normal simple columnar cytoarchitectural patency in late-stage shigellosis.
CDC/ Dr. Sam Formal, Walter Reed Army Institution of Research
December 4, 2012
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